Pore formation phase diagrams for lipid membranes
نویسندگان
چکیده
منابع مشابه
Pore formation in lipid membranes by alamethicin.
The conformation of the linear peptide antibiotic alamethicin in dipalmitoyl phosphatidylcholine multilayers was investigated in the absence of an electric field by means of infrared attenuated total reflection spectroscopy. Alamethicin was found to be incorporated into the lipid membrane not only in the dry state but also in an aqueous environment. Its molecular conformation, however, changed ...
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We investigated the effect of charge on the membrane morphology of giant unilamellar vesicles (GUVs) composed of various mixtures containing charged lipids. We observed the membrane morphologies by fluorescent and confocal laser microscopy in lipid mixtures consisting of a neutral unsaturated lipid [dioleoylphosphatidylcholine (DOPC)], a neutral saturated lipid [dipalmitoylphosphatidylcholine (...
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We study the nucleation of a single pore in a fluctuating lipid membrane, specifically taking into account the membrane fluctuations, as well as the shape fluctuations of the pore. For large enough pores, the nucleation free energy is well-described by shifts in the effective membrane surface tension and the pore line tension. Using our framework, we derive the stability criteria for the variou...
متن کاملPore theory in pure lipid membranes
The movement of ions through the cell membrane is in the literature and in textbooks explained by the action of protein ion channels. An exception is the field of electroporation. Electroporation is a temporary reversible electrical breakdown induced by lipid channels in the membrane. The lipid channels are caused by large trans membrane voltages, hence the pore models of electroporation are no...
متن کاملAlamethicin-induced pore formation in biological membranes.
The effects of alamethicin on the membrane barrier function of rabbit erythrocytes, human platelets and sarcoplasmic reticulum vesicles, as well as on that of brain microsomes and liver mitochondria of the rat were compared. An upset of the barrier function was observed for plasma membranes of brain microsomes as well as for erythrocyte and platelet membranes at alamethicin concentrations rangi...
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ژورنال
عنوان ژورنال: JETP Letters
سال: 2014
ISSN: 0021-3640,1090-6487
DOI: 10.1134/s0021364014060095